DENVER — Parts of Interstate 25 and Interstate 70 will be closed through the night and may reopen Thursday morning, according to the Colorado Department of Transportation.

I-25 will stay closed at least between Lone Tree and Monument. I-70 will stay closed between Denver and the Kansas border.

Earlier Wednesday, southbound I-25 was closed between Lincoln Avenue in Lone Tree to Monument Hill because of a 40-car pileup in Douglas County. As of 6 p.m., the closure had grown to a 42-mile stretch in both directions between mile markers 150 (North Academy Boulevard) and 192 (RidgeGate Parkway).

According to the Douglas County Sheriff’s Office, CDOT hopes to have I-25 fully reopened between the Denver area and Colorado Springs by 4 a.m. Thursday.